2. Signaling Pathways
  3. Vitamin D Related/Nuclear Receptor
  4. Thyroid Hormone Receptor
  5. Thyroid Hormone Receptor Antagonist

Thyroid Hormone Receptor Antagonist

Thyroid Hormone Receptor Antagonists (9):

Cat. No. Product Name Effect Purity
  • HY-156679
    VK-0214
    		Antagonist 99.74%
    VK-0214 is an agonist for thyroid beta receptor (TRβ), which ameliorates the X-linked adrenoleukodystrophy (X-ALD), through activation of ABCD2 expression and reduction of very long chain fatty acids (VLCFA) accumulation.
  • HY-141513
    NH-3
    		Antagonist 99.41%
    NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC50 of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment. NH-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
  • HY-111443
    TR antagonist 1
    		Antagonist 99.57%
    TR antagonist 1 is a high-affinity thyroid hormone receptor (TR) antagonist with IC50s of 36 and 22 nM for TRα and TRβ, respectively.
  • HY-P2426
    (D-Trp12,Tyr34)-pTH (7-34) amide (bovine)
    		Antagonist 99.16%
    (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) is a potent and competitive antagonist of parathyroid hormone (PTH), with a Ki of 69 nM in bovine renal cortical membrane. (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) can be used for growth and development regulation.
  • HY-148350
    DS69910557
    		Antagonist 99.47%
    DS69910557 is a potent, selective and orally activehuman parathyroid hormone receptor 1 (hPTHR1) antagonist. DS69910557 has antagonistic activity for PTHR1 with an IC50 value of 0.08 μM. DS69910557 can be used for the research of hyperparathyroidism, hypercalcemia of malignancy and osteoporosis.
  • HY-P2279A
    Parathyroid hormone (1-34) (rat) acetate
    		Antagonist 99.87%
    Parathyroid hormone (1-34) (rat) (acetate) is a parathyroid hormone. Parathyroid hormone (1-34) (rat) improves both cortical and cancellous bone structure. Parathyroid hormone (1-34) (rat) can be used for the research of osteoporosis.
  • HY-125879
    DS08210767
    		Antagonist 99.75%
    DS08210767 is a highly potent, orally bioavailable PTHR1 antagonist with IC50 of 90 nM.
  • HY-111442
    GC 14
    		Antagonist
    GC 14 is a selective thyroid hormone receptor antagonist, with IC50 values of 35 nM and 200 nM for hTRβ and hTRα, respectively.
  • HY-127024
    Thyroid hormone receptor antagonist (1-850)
    		Antagonist
    Thyroid hormone receptor antagonist (1-850) is a competitive, selective and high-affinity thyroid hormone receptor (TR) antagonist with an IC50 of 1.5 μM for antagonizing the effect of T3 on TR. Thyroid hormone receptor antagonist (1-850) blocks T3-mediated interaction of TRα and TRβ with nuclear receptor coactivator. Thyroid hormone receptor antagonist (1-850) has no effect on the activity of RARα.